Postmenopausal Hormone Treatment

Postmenopausal hormone treatment.

Context: Observational studies have found lower rates of coronary heart disease (CHD) in postmenopausal women who take estrogen than in women who do not, but this potential benefit has not been confirmed in clinical trials. Objective: To determine if estrogen plus progestin therapy alters the risk for CHD events in postmenopausal women with established coronary disease. Design: Randomized, blin...

Postmenopausal hormone replacement therapy.

Several comprehensive accounts of postmenopausal hormone replacement treatment have been published in the United Kingdom in the past year`so in this review we concentrate on areas which, while often controversial, are of concern to the practising physician. We discuss the effects of postmenopausal hormone replacement therapy on the risks of developing coronary heart disease, osteoporosis, and c...

Postmenopausal hormone therapy: a reversal of fortune.

How did it become common clinical practice in past decades to prescribe postmenopausal hormones for the prevention of coronary heart disease (CHD)? Postmenopausal hormone therapy (HT), although approved by the US Food and Drug Administration for the treatment of postmenopausal symptoms and the prevention of osteoporosis, was never approved for the prevention of CHD. The recent data from the Wom...

Postmenopausal hormone therapy: does it cause incontinence?

OBJECTIVE To estimate the effect of hormone therapy on risk of stress and urge urinary incontinence. METHODS The Heart Estrogen/progestin Replacement Study was a randomized, placebo-controlled, double-blinded trial to evaluate daily oral conjugated estrogen (0.625 mg) plus medroxyprogesterone acetate (2.5 mg) therapy for the prevention of heart disease events in women with established heart d...

Where postmenopausal hormone therapy stands today.